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Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles

Title
Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles
Authors
Kyeongah Kang;Dae-Hyoun Lim;Jong-Seok Lim;Myeong-Sok Lee;Young Yang;Eun-Yi Moon;Kangtaek Lee;Taegyeong Kang;In-Hong Choi
Issue Date
2011
Journal Title
Toxicology Letters
ISSN
0378-4274
Citation
Toxicology Letters, Vol.205(3) : 227~234, 2011
Abstract
Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials due to their antibacterial properties. In this study, we examined the effects of polyvinylpyrrolidone (PVP)-coated AgNPs (average size 2.3nm) on angiogenesis in both an in vivo model and an in vitro endothelial cell line, SVEC4-10. Increased angiogenesis was detected around the injection site of AgNP-containing Matrigel in vivo. AgNPs also increased the infiltration of endothelial cells and the hemoglobin (Hb) content in AgNP-Matrigel plugs implanted into mice. AgNPs induced endothelial cell tube formation on growth factor-reduced Matrigel, production of reactive oxygen species (ROS), and production of angiogenic factors, such as vascular endothelial growth factor (VEGF) and nitric oxide (NO), in SVEC4-10 cells. In addition, AgNPs promoted the activation of FAK, Akt, ERK1/2, and p38, which are all involved in VEGF receptor (VEGFR)-mediated signaling. Finally, AgNP-treated tumors caused angiogenesis around tumors in B16F10 melanomas after they were injected into mice, and the Hb concentration in the tumors increased in a concentration-dependent manner with AgNP treatment. Thus, our study suggests that exposure to AgNPs can cause angiogenesis through the production of angiogenic factors.
URI
http://www.sciencedirect.com/science/article/pii/S0378427411012513

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93990
DOI
10.1016/j.toxlet.2011.05.1033
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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