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Effects of HB-EGF and epiregulin on wound healing of gingival cells in vitro.

Authors
 Y-J Yoo ; JM Kim ; J-H Cha ; W-S Park ; S-T Kim ; JY Chang ; EJ Bak 
Citation
 Oral Diseases, Vol.17(8) : 785~793, 2011 
Journal Title
 Oral Diseases 
ISSN
 1354-523X 
Issue Date
2011
Abstract
OBJECTIVE: Gingival wound healing is important to periodontal disease and surgery. This in vitro study was conducted to assess the manner in which heparin-binding epidermal growth factor-like growth factor (HB-EGF) and epiregulin cooperatively participate in the wound-healing process in the gingival epithelial and fibroblast cells of the oral mucosa. MATERIAL AND METHODS: Gingival epithelium and fibroblast were separated from gingival tissue biopsies and prepared to primary cultures. The changes in the mRNA expression were evaluated via real-time PCR. The effects on cell proliferation, migration, and repopulation were evaluated in vitro. RESULTS: The different regulation of expressions of HB-EGF, epiregulin, and epidermal growth factor receptors was observed over time and with different gingival cell types. HB-EGF exerted a cell migration-inducing effect on both epithelial and fibroblast cells, whereas epiregulin did not. Both growth factors functioned as mitogens for epithelial cell proliferation, but not for fibroblast proliferation. HB-EGF strongly promoted epithelial cell repopulation and mildly promoted fibroblast repopulation, whereas epiregulin promoted only fibroblast repopulation. CONCLUSION: These results indicated that both growth factors might function importantly in the wound-healing process of human gingival tissue via the different regulation of the expression, cell migration, proliferation, and repopulation.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93909
DOI
10.1111/j.1601-0825.2011.01836.x
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Prosthodontics
1. 연구논문 > 2. College of Dentistry > Dept. of Advanced General Dentistry
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
1. 연구논문 > 5. Research Institutes > Oral Cancer Research Institute
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01836.x/abstract;jsessionid=A26F69BD8958EC9EDCDD2B436F074799.f01t01
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