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Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia

Authors
 권자영 ; 권재현 ; 김영한 ; 박용원 
Citation
 Journal of Perinatal Medicine, Vol.39(5) : 507~513, 2011 
Journal Title
 Journal of Perinatal Medicine 
ISSN
 0300-5577 
Issue Date
2011
Abstract
BACKGROUND: We determined serum endogenous secretory receptor of advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) concentrations and the esRAGE/sRAGE ratio in normal pregnancy and preeclampsia because esRAGE and sRAGE have been negatively linked to components of metabolic syndromes and pathologic pregnancy including preeclampsia. METHOD: Eighty-seven normal pregnant women and 28 with preeclampsia were recruited. Serum sRAGE and esRAGE levels were measured by enzyme-linked immunosorbent assay. RESULTS: There were significant differences in esRAGE concentration and esRAGE/sRAGE ratio between 1(st) and 3(rd) trimester in normal pregnancy (P=0.007 and P=0.003). Serum esRAGE concentrations and esRAGE/sRAGE ratio in patients with preeclampsia significantly increased compared to controls (P=0.005 and P<0.001). CONCLUSIONS: Maternal serum esRAGE concentration and esRAGE/sRAGE ratio (1) gradually decrease with gestational age in normal pregnancy; and (2) are higher in patients with preeclampsia than healthy pregnant controls, significantly. Serum esRAGE and esRAGE/sRAGE ratio might be associated with preeclampsia.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93889
DOI
10.1515/jpm.2011.055
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
Yonsei Authors
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Link
 http://www.degruyter.com/view/j/jpme.2011.39.issue-5/jpm.2011.055/jpm.2011.055.xml
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