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Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia

Title
 Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia 
Authors
 Jae-Hyun Kwon ; Young-Han Kim ; Yong-Won Park ; Ja-Young Kwon 
Issue Date
2011
Journal Title
 Journal of Perinatal Medicine 
ISSN
 0300-5577 
Citation
 Journal of Perinatal Medicine, Vol.39(5) : 507~513, 2011 
Abstract
BACKGROUND: We determined serum endogenous secretory receptor of advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) concentrations and the esRAGE/sRAGE ratio in normal pregnancy and preeclampsia because esRAGE and sRAGE have been negatively linked to components of metabolic syndromes and pathologic pregnancy including preeclampsia. METHOD: Eighty-seven normal pregnant women and 28 with preeclampsia were recruited. Serum sRAGE and esRAGE levels were measured by enzyme-linked immunosorbent assay. RESULTS: There were significant differences in esRAGE concentration and esRAGE/sRAGE ratio between 1(st) and 3(rd) trimester in normal pregnancy (P=0.007 and P=0.003). Serum esRAGE concentrations and esRAGE/sRAGE ratio in patients with preeclampsia significantly increased compared to controls (P=0.005 and P<0.001). CONCLUSIONS: Maternal serum esRAGE concentration and esRAGE/sRAGE ratio (1) gradually decrease with gestational age in normal pregnancy; and (2) are higher in patients with preeclampsia than healthy pregnant controls, significantly. Serum esRAGE and esRAGE/sRAGE ratio might be associated with preeclampsia.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93889
DOI
10.1515/jpm.2011.055,
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
Yonsei Authors
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Link
 http://www.degruyter.com/view/j/jpme.2011.39.issue-5/jpm.2011.055/jpm.2011.055.xml
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