Cited 15 times in

Involvement of IL-10 gene promoter polymorphisms in the susceptibility for childhood asthma

Title
Involvement of IL-10 gene promoter polymorphisms in the susceptibility for childhood asthma
Authors
Kyung Won Kim;Kyung Eun Lee;Kyu-Earn Kim;Myung Hyun Sohn;Won Il Heo;Mi Na Kim;Jung Yeon Hong
Issue Date
2011
Journal Title
Lung
ISSN
0341-2040
Citation
Lung, Vol.189(5) : 417~423, 2011
Abstract
Asthma and atopy have a complex background that may result from the interaction of genes and the environment. Interleukin (IL)-10 is known to play various roles in immune-regulating and anti-inflammatory responses. The aim of this study was to evaluate the possible effect of the IL-10 promoter polymorphisms on susceptibility to childhood asthma. We recruited 333 patients with atopic asthma, 55 with nonatopic asthma, and 248 normal controls. We performed a genetic association study of three genetic polymorphisms (IL-10 -1082A>G, IL-10 -819T>C, and IL-10 -592A>C) of the IL-10 promoter. There was no difference between atopic asthma, nonatopic asthma, and normal controls with respect to allele, genotype, or haplotype frequencies of these IL-10 polymorphisms. However, the -1082A>G polymorphism and ATA haplotype in the IL-10 promoter gene were associated with airway hyper responsiveness (AHR) and the -819T>C, -592A>C, and ATA and ACC haplotypes were also shown to be related to serum eosinophil cationic protein (ECP). Our results suggest that the polymorphisms within the IL-10 promoter may have a disease-modifying effect in the asthmatic airway.
URI
http://link.springer.com/article/10.1007%2Fs00408-011-9312-5

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93715
DOI
10.1007/s00408-011-9312-5
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse