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Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans.

Title
Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans.
Authors
Eun Seok Kang;Faidon Magkos;Christos S. Mantzoros;Elizabeth Sienkiewicz
Issue Date
2011
Journal Title
European Journal of Endocrinology
ISSN
0804-4643
Citation
European Journal of Endocrinology, Vol.164(6) : 911~917, 2011
Abstract
OBJECTIVE: Animal and in vitro studies indicate that leptin alleviates starvation-induced reduction in circulating vaspin and stimulates the production of visfatin. We thus examined whether vaspin and visfatin are affected by short- and long-term energy deprivation and leptin administration in human subjects in vivo. DESIGN AND METHODS: We measured circulating levels of vaspin and visfatin i) before and after 72 h of starvation (leading to severe hypoleptinemia) with or without leptin administration in replacement doses in 13 normal-weight subjects, ii) before and after 72 h of starvation with leptin administration in pharmacological doses in 13 lean and obese subjects, iii) during chronic energy deficiency in eight women with hypothalamic amenorrhea on leptin replacement for 3 months, and iv) during chronic energy deficiency in 18 women with hypothalamic amenorrhea on leptin replacement or placebo for 3 months. RESULTS: Acute starvation decreased serum leptin to 21% of baseline values, (P=0.002) but had no significant effect on vaspin and visfatin concentrations (P>0.05). Nor did normalization of leptin levels affect the concentrations of these two adipokines (P>0.9). Leptin replacement in women with hypothalamic amenorrhea did not significantly alter vaspin and visfatin concentrations, whether relative to baseline or placebo administration (P>0.25). Pharmacological doses of leptin did not affect circulating vaspin and visfatin concentrations (P>0.9). CONCLUSIONS: Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency leading to hypoleptinemia and are not regulated by leptin in human subjects, indicating that these adipocyte-secreted hormonal regulators of metabolism are independently regulated in humans.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93686
DOI
10.1530/EJE-11-0052.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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