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Grp78 is a Novel Downstream Target Gene of Hoxc8 Homeoprotein

Title
Grp78 is a Novel Downstream Target Gene of Hoxc8 Homeoprotein
Authors
Kang Jin-Joo;Bok Jin-Woong;Kim Myoung-Hee
Issue Date
2011
Journal Title
Journal of experimental and biomedical sciences (대한의생명과학회지)
ISSN
1738-3226
Citation
Journal of experimental and biomedical sciences (대한의생명과학회지), Vol.17(1) : 1~5, 2011
Abstract
Previously, we have identified 14 putative downstream target genes of Hoxc8 homeoprotein in F9 murine embryonic teratocarcinoma cells through proteomics analysis. Among those, we tested a possibility of a DNA-k type molecular chaperone, Grp78, as a direct downstream target of Hoxc8, by cloning a 2.4 kb upstream region of murine Grp78 into a reporter plasmid and by testing if Hoxc8 can regulate its expression. We observed that Hoxc8 proteins could transactivate the reporter gene, which was affected by small interference RNAs (siRNAs) against to Hoxc8, suggesting that Grp78 is a novel downstream target of Hoxc8 in vivo.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93685
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anatomy
Yonsei Authors
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