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호산구 식도염의 임상병리학적 특징 분석: 비폐쇄성 연하곤란과의 비교 연구

Title
호산구 식도염의 임상병리학적 특징 분석: 비폐쇄성 연하곤란과의 비교 연구
Other Titles
Analysis of the Clinicopathologic Features of Eosinophilic Esophagitis: Comparative Study with Nonobstructive Dysphagia
Authors
김광현;정일형;이상인;박효진;윤선옥;윤영훈;김지현
Issue Date
2011
Journal Title
Korean Journal of Gastrointestinal Endoscopy (대한소화기내시경학회지)
ISSN
1225-7001
Citation
Korean Journal of Gastrointestinal Endoscopy (대한소화기내시경학회지), Vol.42(3) : 143~151, 2011
Abstract
Background/Aims: Eosinophilic esophagitis (EoE) has emerged as one of the most common causes of dysphagia and esophageal food impactions. However, it is doubtful that gastroenterologists and pathologists make the correct diagnosis of EoE because of the insufficient recognition of EoE based on the endoscopic and pathological findings. This study was performed to investigate the symptoms and the endoscopic and pathologic findings of EoE as compared with those of nonobstructive dysphagia (NOD). Methods: We retrospectively reviewed the medical records and the endoscopic and pathologic findings from 12 patients who were diagnosed with EoE based on an eosinophil count of ≥20 per high-power field (HPF) and 13 patients diagnosed with NOD, and these patients were treated at our hospital from June 2006 till October 2010. Results: The endoscopic findings of EoE included rings (41.7%), furrows (75.0%), exudates (33.3%), mucosal friability (8.3%) and multi-findings (6.7%). Furrows and multi-findings were identified more frequently in EoE as comparison to that in NOD. The pathologic findings revealed that the maximal eosinophil counts/HPF were 87.2 (range 20∼232) and 2.2 (0∼11) in EoE and NOD, respectively. Moreover, eosinophil microabscess (58.3%), degranulation (100%) and spongiosis (91.7%) were more significantly observed in EoE compared with that in NOD. Conclusions: EoE had specific endoscopic and clinicopathologic features that distinguish it from NOD. For patients with dysphagia, the endoscopic and pathologic findings of EoE should be kept in mind
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93680
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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