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Cytologic characteristics and β-catenin immunocytochemistry on smear slide of cribriform-morular variant of papillary thyroid carcinoma

Title
Cytologic characteristics and β-catenin immunocytochemistry on smear slide of cribriform-morular variant of papillary thyroid carcinoma
Authors
Koo J.S.;Jung W.;Hong S.W
Issue Date
2011
Journal Title
Acta Cytologica
ISSN
0001-5547
Citation
Acta Cytologica, Vol.55(1) : 13~18, 2011
Abstract
OBJECTIVE: The purpose of this study is to analyze the characteristic cytologic features of the cribriform-morular variant of papillary thyroid carcinoma (CVPTC) and to find out the possibility of a preoperative diagnosis of CVPTC in fine needle aspiration (FNA). STUDY DESIGN: A retrospective review of cytologic features of 5 patients who were diagnosed with CVPTC after thyroidectomy and underwent preoperative FNA was performed. In addition, β-catenin immunocytochemistry on a smear slide was applied. RESULTS: All cases showed a high cellularity smear, cribriform architecture, ovoid/columnar cells, obvious nucleoli, and nuclear groove. Epithelial morules were observed in 4 (80%) cases. All cases demonstrated a nuclear and cytoplasmic expression in β-catenin immunocytochemistry applied to a smear slide. CONCLUSION: Preoperative diagnosis of CVPTC can be made by cytologic features of cribriform architecture, epithelial morule, and columnar cells in FNA and β-catenin immunocytochemistry on a smear slide showing a nuclear and cytoplasm expression.
URI
http://www.karger.com/?DOI=000320856

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93672
DOI
10.1159/000320856
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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