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The expression of ERCC1, RRM1, and BRCA1 in breast cancer according to the immunohistochemical phenotypes.

Authors
 Dokyung Kim ; Woohee Jung ; Ja Seung Koo 
Citation
 Journal of Korean Medical Science, Vol.26(3) : 352~359, 2011 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2011
Abstract
We studied the expression of BRCA1, ERCC1, and RRM1 which play an important role in DNA repair systems in breast cancer. Immunohistochemical staining for EGFR, BRCA1, ERCC1, and RRM1 were performed by using a tissue microarray made from 230 breast cancer patients. Patients were classified into luminal A, luminal B, HER-2, and triple negative breast cancer (TNBC) types according to ER, PR, and HER-2 expression. The expression of ERCC1, RRM1, and BRCA1 were correlated (P < 0.05). The expression level of ERCC1 was the lowest in TNBC type (P = 0.031), ERCC1 negativity was more prominent in TNBC and luminal B groups than luminal A and HER-2 groups (P = 0.013). Cases with EGFR overexpression showed high expression of RRM1 and BRCA1 (P = 0.046, and 0.004, respectively). In conclusion, the expression of ERCC1 is particularly lower in TNBCs than other types of breast cancers.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93671
DOI
10.3346/jkms.2011.26.3.352
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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