A New Shock Index for Predicting Survival of Rats with
Hemorrhagic Shock Using Perfusion and Lactate Concentration Ratio
최재림 ; 남기창 ; 김덕원 ; 장경환 ; 권민경
Journal of The Institute of Electronics Engineers of Korea (전자공학회논문지 - SC)
Journal of The Institute of Electronics Engineers of Korea (전자공학회논문지 - SC), Vol.48(4) : 257~265, 2011
Hemorrhagic shock is a clinically widespread syndrome characterized by inadequate oxygenation and supply. It is
important to diagnose hemorrhagic shock in its early stage for improving treatment effects and survival rate. However, an
accurate diagnosis and treatment could be delayed in the early stage of hemorrhagic shock by evaluating only vital signs
such as heart rate and blood pressure. There have been many studies for the early diagnosis of hemorrhagic shock,
reporting that lactate concentration and perfusion were useful variables for tissue hypoxia and metabolic acidosis. In this
study, we measured both perfusion using a laser Doppler flowmeter and lactate concentration from the volume controlled
hemorrhagic shock using rats. We also proposed a new shock index which was calculated by dividing lactate concentration
by perfusion for early diagnosis. As a result of the survival prediction by the proposed index with the receiver operating
characteristic curve method, the sensitivity, specificity, and accuracy of survival were 90.0, 96.7 and 94.0%, respectively.
The proposed index showed the fastest significant difference among the other parameters such as blood pressure and heart
rate. It could offer early diagnosis and effective treatment for human hemorrhagic shock if it is applicable to humans.