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Subthreshold continuous electrical stimulation facilitates functional recovery of facial nerve after crush injury in rabbit

Title
 Subthreshold continuous electrical stimulation facilitates functional recovery of facial nerve after crush injury in rabbit 
Authors
 Jin Kim ; Su Jin Han ; Jae Young Choi ; Won-sang Lee ; Dong Hyun Shin 
Issue Date
2011
Journal Title
 Muscle & Nerve 
ISSN
 0148-639X 
Citation
 Muscle & Nerve, Vol.43(2) : 251~258, 2011 
Abstract
We sought to determine whether electrical stimulation (ES) with subthreshold, continuous, low-frequency impulses is a viable clinical method for improving functional recovery after facial nerve crush injury. In 10 rabbits, bilateral crush injuries were made on the facial nerve by compression for 30 s with mosquito forceps, causing complete facial paralysis. Subthreshold continuous direct current ES with 20-Hz square-wave pulses was applied to the proximal stump on one side for 4 weeks. Vibrissae movement returned significantly earlier on the ES side, with a less variable recovery time. Electrophysiologically, the stimulated side had a significantly shorter latency, longer duration, and faster conduction velocity. Light and transmission electron microscopy revealed that the electrical stimulation also markedly decreased Wallerian degeneration. The average numbers of fluorescent, double-labeled nerve cells were significantly different between the ES and non-ES sides. This study shows that subthreshold, continuous, low-frequency ES immediately after a crush injury of the facial nerve results in earlier recovery of facial function and shorter overall recovery time
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93608
DOI
10.1002/mus.21840
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/mus.21840/abstract
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