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The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

Title
 The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer
Authors
 Ja Seung Koo; Seho Park; Byeong-Woo Park; Sarah Lee; Seung Il Kim
Issue Date
2011
Journal Title
 Tumor Biology
ISSN
 1010-4283
Citation
 Tumor Biology, Vol.32(4) : 787~799, 2011
Abstract
We aimed to investigate the expression of caveolin-1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93605
DOI
10.1007/s13277-011-0181-6
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs13277-011-0181-6
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