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Self-assembled and nanostructured siRNA delivery systems

Authors
 Ji Hoon Jeong ; Tae Gwan Park ; Sun Hwa Kim 
Citation
 Pharmaceutical Research, Vol.28(9) : 2072~2085, 2011 
Journal Title
 Pharmaceutical Research 
ISSN
 0724-8741 
Issue Date
2011
Abstract
A wide range of organic and inorganic materials have been used in the development of nano-scale self-assembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93584
DOI
10.1007/s11095-011-0412-y
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs11095-011-0412-y
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