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Self-assembled and nanostructured siRNA delivery systems

Authors
 Ji Hoon Jeong  ;  Tae Gwan Park  ;  Sun Hwa Kim 
Citation
 PHARMACEUTICAL RESEARCH, Vol.28(9) : 2072-2085, 2011 
Journal Title
PHARMACEUTICAL RESEARCH
ISSN
 0724-8741 
Issue Date
2011
MeSH
Animals ; Cations ; Drug Carriers/chemistry* ; Drug Stability ; Gene Silencing/drug effects ; Humans ; Lipids/chemistry ; Nanoparticles/chemistry* ; Oligonucleotides, Antisense/administration & dosage ; Particle Size ; Peptides/chemistry ; Plasmids/administration & dosage ; Polyethylene Glycols/chemistry ; RNA, Small Interfering/administration & dosage* ; RNA, Small Interfering/pharmacology
Keywords
non-viral gene carriers ; PEGylated polyplex ; self-assembled nanostructures ; siRNA medicines ; siRNA-PEG conjugates
Abstract
A wide range of organic and inorganic materials have been used in the development of nano-scale self-assembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings.
Full Text
http://link.springer.com/article/10.1007%2Fs11095-011-0412-y
DOI
10.1007/s11095-011-0412-y
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Kim, Sun Hwa(김선화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93584
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