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Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Authors
 Eun-Kyung Lim ; Eunji Jang ; Seungjoo Haam ; Yong-Min Huh ; Jin-Suck Suh ; Kwangyeol Lee ; Jihye Choi ; Bongjune Kim 
Citation
 Journal of Materials Chemistry, Vol.21 : 12473~12478, 2011 
Journal Title
 Journal of Materials Chemistry 
ISSN
 0959-9428 
Issue Date
2011
Abstract
We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophagevia MR imaging.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93560
DOI
10.1039/C1JM10764J
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://pubs.rsc.org/en/content/articlelanding/2011/jm/c1jm10764j#!divAbstract
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