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Topiramate on the quality of life in childhood epilepsy.

Title
Topiramate on the quality of life in childhood epilepsy.
Authors
Da-Eun Jung;Heung-Dong Kim;Korean Pediatric Topiramate Study Group;So-Yong Eom;Yun-Jung Hur
Issue Date
2011
Journal Title
Brain & Development
ISSN
0387-7604
Citation
Brain & Development, Vol.33(9) : 707~712, 2011
Abstract
This study evaluated the effect of topiramate (TPM) on the quality of life (QOL) in childhood epilepsy, using the Korean quality of life in childhood epilepsy (K-QOLCE) questionnaire. An open label, prospective, observational study of the families of 664 children with epilepsy from 41 centers was conducted. The parents completed the K-QOLCE at the baseline visit and again 6months after starting TPM treatment. The parents reported the seizure frequency at both assessment dates. Statistically significant improvements in all K-QOLCE domains except social functioning were found at 6months after starting TPM treatment from the baseline-scores (P<0.05). However, improved QOL scores were not dependent on the reduction in seizure frequency. TPM significantly improved QOL in children with epilepsy, suggesting its potential clinical benefits.
URI
http://www.sciencedirect.com/science/article/pii/S0387760410002986

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93558
DOI
10.1016/j.braindev.2010.11.011
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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