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정상 신기능 가진 성인에서 Cystatin C와 Visceral Fat과의 연관성

Other Titles
 Association between Serum Cystatin C Level and Visceral Fat in Healthy Individuals with Normal Kidney Function 
Authors
 홍정아 ; 이광미 ; 이지원 ; 손유나 
Citation
 Korean Journal of Family Medicine, Vol.1(2) : 94~100, 2011 
Journal Title
 Korean Journal of Family Medicine 
ISSN
 1225-4908 
Issue Date
2011
Abstract
Background: Visceral abdominal fat is a known risk factor for the kidney diseases and cystatin C which is a better marker for kidney function is increased in obese patients. The aim of this study is to evaluate the correlation between the visceral adiposity measured by computed tomography (CT) of the abdomen and serum cystatin C level in healthy individuals with normal kidney function. Methods: 318 Healthy individuals with glomerular fi ltration rate (GFR) greater than 60 mL/min/1.73 m2 were included in the study. The questionnaire, physical measurements, blood testing, and CT for visceral fat measurement were carried out. The association between visceral fat and serum cystatin C level or kidney function was investigated by using Pearson' correlation and multiple regression analysis. Results: Signifi cant positive correlation was found between visceral fat and cystatin C (r = 0.284, P < 0.001) where as negative correlation was observed between visceral fat and eGFRcys (r = −0.820, P < 0.001). After adjustment for confounding variants, the multiple regression analysis demonstrated signifi cant positive correlation between the visceral fat area and serum cystatin C level (P = 0.013) and signifi cant negative correlation between visceral fat and eGFRcys. Conclusion: In healthy individuals with normal kidney function, the visceral fat was independently associated with the cystatin C level, a marker for early detection of renal dysfunction, which indicates the possible relationship between the visceral fat and renal dysfunction prior to development of the kidney disease.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93552
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
Yonsei Authors
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