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Factors associated with participation in providing buccal cell DNA for a genetic epidemiologic study

Authors
 강대용 ; 김창수 ; 서일 ; 허남욱 
Citation
 Public Health Genomics, Vol.14(3) : 127~134, 2011 
Journal Title
 Public Health Genomics 
ISSN
 1662-4246 
Issue Date
2011
Abstract
AIMS: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. METHODS: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. RESULTS: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≥3 μg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) (<18.5 kg/m(2)), blood pressure, total cholesterol, and fasting blood glucose level were negatively associated with participation in men after adjustments for age and family history of chronic disease, but not in women, except for low BMI. CONCLUSIONS: In this study, collecting buccal cell DNA by mailed survey has a low success rate (29%), and there appear to be a nonresponse bias and gender differences in the collection process.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93517
DOI
10.1159/000318808
Appears in Collections:
1. 연구논문 > 4. Graduate School of Public Health > Graduate School of Public Health
1. 연구논문 > 5. Research Institutes > Institute for Environmental Research
1. 연구논문 > 1. College of Medicine > Dept. of Preventive Medicine
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Link
 http://www.karger.com/Article/FullText/318808
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