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Uric acid as a potential disease modifier in patients with multiple system atrophy

Authors
 Ji E. Lee ; Sook K. Song ; Phil Hyu Lee ; Young H. Sohn 
Citation
 Movement Disorders, Vol.26(8) : 1533~1536, 2011 
Journal Title
 Movement Disorders 
ISSN
 0885-3185 
Issue Date
2011
Abstract
BACKGROUND: Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy. METHODS: We evaluated the influence of serum uric acid levels on disease progression in 52 patients with multiple system atrophy using changes in the annualized Unified Multiple System Atrophy Rating Scale scores. RESULTS: The mean annualized Unified Multiple System Atrophy Rating Scale changes were significantly lower in patients with the highest uric acid quartile compared with those with the lowest quartile (8.4 ± 5.1 vs 20.2 ± 16.0, P = .038). Serum uric acid levels had a significant negative correlation with the annualized Unified Multiple System Atrophy Rating Scale changes (r = -0.40, P = .004). Multiple linear regression analysis showed that only serum uric acid concentration was significantly correlated with the annualized Unified Multiple System Atrophy Rating Scale changes (β = -2.687, P = .011). CONCLUSIONS: These data suggest that serum uric acid may act as a potential disease modifier in multiple system atrophy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93491
DOI
10.1002/mds.23556
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/mds.23556/abstract
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