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Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia.

Authors
 Na Rae Kim  ;  Eun Suk Lee  ;  Gong Je Seong  ;  Sung Yong Kang  ;  Ji Hyun Kim  ;  Samin Hong  ;  Chan Yun Kim 
Citation
 BRITISH JOURNAL OF OPHTHALMOLOGY, Vol.95(8) : 1115-1121, 2011 
Journal Title
BRITISH JOURNAL OF OPHTHALMOLOGY
ISSN
 0007-1161 
Issue Date
2011
MeSH
Adult ; Aged ; Female ; Fourier Analysis ; Glaucoma/etiology ; Glaucoma/pathology* ; Humans ; Male ; Middle Aged ; Myopia/complications ; Myopia/pathology* ; Nerve Fibers/pathology* ; ROC Curve ; Retinal Ganglion Cells/pathology* ; Sensitivity and Specificity ; Tomography, Optical Coherence/methods* ; Young Adult
Abstract
AIM: To compare the diagnostic ability to detect glaucomatous changes between peripapillary retinal nerve fibre layer (RNFL) thickness and the macular ganglion cell complex (GCC) in highly myopic patients using Fourier domain optical coherence tomography.

METHODS: Participants, consecutively enrolled from January 2009 to June 2009, were imaged with RTVue-100 (NHM4 and MM7 scan). The sensitivity and specificity of a colour code less than 5% (red or yellow) for glaucoma diagnosis were calculated. Area under the receiver operator characteristic (AUROC) curves were generated to assess the ability of each parameter to detect glaucomatous changes.

RESULTS: 73 normal controls and 77 glaucoma patients were included. Participants were categorised as 105 non-high myopes (spherical equivalent >-6.0 dioptres) and 45 high myopes (Spherical equivalent ≤-6.0 dioptres). The GCC thickness showed a strong correlation with RNFL thickness (correlation coefficient=0.763, p<0.001) in all participants. The sensitivity from superior GCC colour code was significantly higher than that from superior RNFL (p=0.019). The ability to detect glaucomatous changes in the highly myopic group by examining the average GCC thickness (AUROC, GCC; 0.889) was higher than when examining RNFL thickness (AUROC, RNFL; 0.825); however, there was no statistical significance (p=0.442).

CONCLUSIONS: The ability to diagnose glaucoma with macular GCC thickness was comparable with that with peripapillary RNFL thickness in high-myopia patients. Macular GCC thickness measurements may be a good alternative or a complementary measurement to RNFL thickness assessment in the clinical evaluation of glaucoma in patients with high myopia.
Full Text
http://bjo.bmj.com/content/95/8/1115.long
DOI
10.1136/bjo.2010.182493
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Na Rae(김나래)
Kim, Ji Hyun(김지현)
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Eun Suk(이은석)
Hong, Sa Min(홍사민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93441
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