Cited 0 times in

Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs

Title
 Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs
Authors
 Jaemoon Yang; Eun-Sook Lee; Yong-Min Huh; Seungjoo Haam; Seung Hyun Kim; Jin-Suck Suh; Kwangyeol Lee; A-Rum Yoo; Eun-Kyung Lim; Seong-Ho Koh; Min-Young Noh
Issue Date
2011
Journal Title
 Biomaterials
ISSN
 0142-9612
Citation
 Biomaterials, Vol.32(26) : 6174~6182, 2011
Abstract
The synchronization of gene expression and cell trafficking in transfected stem cells is crucial for augmentation of stem cell functions (differentiation and neurotropic factor secretion) and real time in vivo monitoring. We report a magnetic nanoparticle-based gene delivery system that can ensure simultaneous gene delivery and in vivo cell trafficking by high resolution MR imaging. The polar aprotic solvent soluble MnFe₂O₄ nanoparticles were enveloped using cationic polymers (branched polyethyleneimine, PEI) by the solvent shifting method for a gene loading. Using our magnetic nanovector system (PEI-coated MnFe₂O₄ nanoparticles), thus, we synchronized stem cell migration and its gene expression in a rat stroke mod
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93439
DOI
10.1016/j.biomaterials.2011.04.007
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.sciencedirect.com/science/article/pii/S0142961211003899
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse