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Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation

Title
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation
Authors
Joonsung Hwang;Ryosuke Kita;Maria I. Morasso;Mark C. Udey;Seung Hun Lee;Eung Ho Choi;Hyouk-Soo Kwon
Issue Date
2011
Journal Title
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
Citation
Proceedings of the National Academy of Sciences of the United States of America, Vol.108(28) : 11566~11571, 2011
Abstract
In an effort to understand the role of Distal-less 3 (Dlx3) in cutaneous biology and pathophysiology, we generated and characterized a mouse model with epidermal ablation of Dlx3. K14cre;Dlx3(Kin/f) mice exhibited epidermal hyperproliferation and abnormal differentiation of keratinocytes. Results from subsequent analyses revealed cutaneous inflammation that featured accumulation of IL-17-producing CD4(+) T, CD8(+) T, and γδ T cells in the skin and lymph nodes of K14cre;Dlx3(Kin/f) mice. The gene expression signature of K14cre;Dlx3(Kin/f) skin shared features with lesional psoriatic skin, and Dlx3 expression was markedly and selectively decreased in psoriatic skin. Interestingly, cultured Dlx3 null keratinocytes triggered cytokine production that is potentially linked to inflammatory responses in K14cre;Dlx3(Kin/f) mice. Thus, Dlx3 ablation in epidermis is linked to altered epidermal differentiation, barrier development, and IL-17-associated skin inflammation. This model provides a platform that will allow the systematic exploration of the contributions of keratinocytes to cutaneous inflammation.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93434
DOI
10.1073/pnas.1019658108
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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