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Determinants of perimacular inner retinal layer thickness in normal eyes measured by Fourier-domain optical coherence tomography.

Authors
 Na Rae Kim ; Ji Hyun Kim ; Chan Yun Kim ; Gong Je Seong ; Eun Suk Lee ; Junwon Lee 
Citation
 Investigative Ophthalmology & Visual Science, Vol.52(6) : 3413~3418, 2011 
Journal Title
 Investigative Ophthalmology & Visual Science 
ISSN
 0146-0404 
Issue Date
2011
Abstract
PURPOSE: To determine the effects of age, sex, spherical equivalent, axial length, anterior chamber depth, optic disc area, and central corneal thickness on perimacular inner retinal layer thickness in the normal human eye as measured by Fourier-domain optical coherence tomography (FD-OCT). METHODS: In this cross-sectional observational study, 182 Korean healthy subjects aged from 22 to 84 years were included. To obtain the inner retinal layer thickness, perimacular ganglion cell complex thickness, which extends from the internal limiting membrane to the inner nuclear layer, was measured by FD-OCT on one randomly selected eye of each subject. Linear regression analyses of the effects of demographic and clinical variables, including age, sex, spherical equivalent, axial length, anterior chamber depth, optic disc area, and central corneal thickness, on perimacular inner retinal layer thickness were performed. RESULTS: The mean inner retinal layer thickness for the entire population was 93.87 μm. Thinner inner retinal layer measurements were associated with older age (P = 0.010) and greater axial length (P = 0.021). Mean inner retinal layer thickness decreased by approximately 1.59 μm for every decade of age and by approximately 1.56 μm for every 1-mm greater axial length. There was no relationship between inner retinal layer thickness and sex, anterior chamber depth, optic disc area, or central corneal thickness. CONCLUSIONS: Inner retinal layer thickness, as measured by FD-OCT, varies significantly with age and axial length. The effect is small but clinically relevant in the interpretation of inner retinal layer thickness measurements.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93413
DOI
10.1167/iovs.10-6648
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Ophthalmology
Yonsei Authors
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