Cited 2 times in
5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김규언 | - |
dc.contributor.author | 남궁란 | - |
dc.contributor.author | 박문성 | - |
dc.contributor.author | 박민수 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 이철 | - |
dc.date.accessioned | 2014-12-20T16:47:32Z | - |
dc.date.available | 2014-12-20T16:47:32Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0341-2040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93386 | - |
dc.description.abstract | Bronchopulmonary dysplasia is characterized by prolonged oxygen dependency due to compromised gas-exchange capability. This is attributable mainly to inadequate and aberrant alveolarization resulting from insults like hyperoxia. Leukotrienes are associated with hyperoxia-induced inhibition of alveolarization. We hypothesized that a 5-lipoxygenase-activating protein (FLAP) inhibitor given while newborn mice were exposed to 85% oxygen would prevent aberrant alveolarization in a dose- and time-dependent manner. Newborn mice were exposed to either room air or hyperoxia for 14 days. Pups were treated with either vehicle or MK-0591 10, 20, or 40 mg/kg subcutaneously daily for days 1-4, 5-9, or 10-14. On day 14, the lungs were inflated, fixed, and stained for histopathological and morphometric analyses. Hyperoxia groups treated with MK-0591 20 or 40 mg/kg during days P1-P4 or P10-P14 showed alveolarization that resembled that of room air controls while untreated hyperoxia groups showed definite evidence of aberrant alveolarization but no inflammation. In a hyperoxia-exposed newborn mice model, a FLAP inhibitor given during critical window periods may prevent aberration of alveolarization in a dose- and time-dependent manner. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 43~50 | - |
dc.relation.isPartOf | LUNG | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 5-Lipoxygenase-Activating Protein Inhibitors/administration & dosage | - |
dc.subject.MESH | 5-Lipoxygenase-Activating Protein Inhibitors/pharmacology* | - |
dc.subject.MESH | 5-Lipoxygenase-Activating Proteins/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Body Weight | - |
dc.subject.MESH | Bronchopulmonary Dysplasia/enzymology | - |
dc.subject.MESH | Bronchopulmonary Dysplasia/etiology | - |
dc.subject.MESH | Bronchopulmonary Dysplasia/pathology | - |
dc.subject.MESH | Bronchopulmonary Dysplasia/physiopathology | - |
dc.subject.MESH | Bronchopulmonary Dysplasia/prevention & control* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperoxia/chemically induced | - |
dc.subject.MESH | Hyperoxia/drug therapy* | - |
dc.subject.MESH | Hyperoxia/enzymology | - |
dc.subject.MESH | Hyperoxia/pathology | - |
dc.subject.MESH | Hyperoxia/physiopathology | - |
dc.subject.MESH | Indoles/administration & dosage | - |
dc.subject.MESH | Indoles/pharmacology* | - |
dc.subject.MESH | Infant, Newborn | - |
dc.subject.MESH | Injections, Subcutaneous | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Oxygen | - |
dc.subject.MESH | Pulmonary Alveoli/drug effects* | - |
dc.subject.MESH | Pulmonary Alveoli/enzymology | - |
dc.subject.MESH | Pulmonary Alveoli/growth & development | - |
dc.subject.MESH | Pulmonary Alveoli/pathology | - |
dc.subject.MESH | Quinolines/administration & dosage | - |
dc.subject.MESH | Quinolines/pharmacology* | - |
dc.subject.MESH | Time Factors | - |
dc.title | 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Min Soo Park | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.contributor.googleauthor | Moon Sung Park | - |
dc.contributor.googleauthor | Ran Namgung | - |
dc.contributor.googleauthor | Chul Lee | - |
dc.identifier.doi | 10.1007/s00408-010-9264-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01241 | - |
dc.contributor.localId | A01458 | - |
dc.contributor.localId | A01468 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A03253 | - |
dc.relation.journalcode | J02173 | - |
dc.identifier.eissn | 1432-1750 | - |
dc.identifier.pmid | 21052705 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00408-010-9264-1 | - |
dc.subject.keyword | Bronchopulmonary dysplasia | - |
dc.subject.keyword | Hyperoxia | - |
dc.subject.keyword | Alveolarization | - |
dc.subject.keyword | Leukotriene | - |
dc.subject.keyword | 5-Lipoxygenase activating protein | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Namgung, Ran | - |
dc.contributor.alternativeName | Park, Moon Sung | - |
dc.contributor.alternativeName | Park, Min Soo | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Lee, Chul | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Namgung, Ran | - |
dc.contributor.affiliatedAuthor | Park, Moon Sung | - |
dc.contributor.affiliatedAuthor | Park, Min Soo | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 189 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.endPage | 50 | - |
dc.identifier.bibliographicCitation | LUNG, Vol.189(1) : 43-50, 2011 | - |
dc.identifier.rimsid | 27626 | - |
dc.type.rims | ART | - |
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