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통풍의 병태 생리

Title
 통풍의 병태 생리
Other Titles
 Pathophysiology of Gout
Authors
 이광훈; 이수곤
Issue Date
2011
Journal Title
 Korean Journal of Medicine (대한내과학회지)
ISSN
 1226-329X
Citation
 Korean Journal of Medicine (대한내과학회지), Vol.80(3) : 251~254, 2011
Abstract
We reviewed the pathophysiology of gout in this review article. Gout occurs as a response to monosodium urate crystal (MSU) that is present in joints, bones and soft tissue. Hyperuricemia in gout is mainly due to the decreased renal clearance of uric acid and is considered to be the cause of MSU formation. However, hyperuricemia alone does not explain the development of gout. Acute gout attack is due to the response to MSU, which is derived by innate immunity. Tophi are deposits of MSU and cell debris surrounded by granulomatous inflammation.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93340
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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