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A multicenter study on extramammary Paget's disease in Korea

Title
 A multicenter study on extramammary Paget's disease in Korea 
Authors
 Seok-Jong Lee ; Yoon Seok Choe ; Young Ho Won ; Kee Suck Suh ; Jeong-Hyun Shin ; Dong Hoon Shin ; Weon Ju Lee ; Min-Geol Lee ; Mi Woo Lee ; Jee Bum Lee ; You Chan Kim ; Myung Hwa Kim ; Moon Bum Kim ; Ki-Ho Kim ; Il Hwan Kim ; Chang Hun Huh ; Kee Yang Chung ; Hae Young Choi ; Kwang Hyun Cho ; Young Chang Cha ; Sung Ku Ahn ; Hong Dae Jung 
Issue Date
2011
Journal Title
 International Journal of Dermatology 
ISSN
 0011-9059 
Citation
 International Journal of Dermatology, Vol.50(5) : 508~515, 2011 
Abstract
BACKGROUND: There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. METHODS: The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. RESULTS: As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). CONCLUSIONS: In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93339
DOI
10.1111/j.1365-4632.2010.04661.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1365-4632.2010.04661.x/abstract
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