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A multicenter study on extramammary Paget's disease in Korea

A multicenter study on extramammary Paget's disease in Korea
Seok-Jong Lee;Yoon Seok Choe;Young Ho Won;Kee Suck Suh;Jeong-Hyun Shin;Dong Hoon Shin;Weon Ju Lee;Min-Geol Lee;Mi Woo Lee;Jee Bum Lee;You Chan Kim;Myung Hwa Kim;Moon Bum Kim;Ki-Ho Kim;Il Hwan Kim;Chang Hun Huh;Kee Yang Chung;Hae Young Choi;Kwang Hyun Cho;Young Chang Cha;Sung Ku Ahn;Hong Dae Jung
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Journal Title
International Journal of Dermatology
International Journal of Dermatology, Vol.50(5) : 508~515, 2011
BACKGROUND: There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. METHODS: The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. RESULTS: As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). CONCLUSIONS: In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
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