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Crosstalk between platelet-derived growth factor-induced Nox4 activation and MUC8 gene overexpression in human airway epithelial cells

Authors
 Hyun Jik Kim ; Chang-Hoon Kim ; Joo-Heon Yoon ; Yun Soo Bae ; Jeung-Gweon Lee ; Min-Ji Kim ; Sang-Nam Lee ; Jung Hee Joo ; Ji-Hwan Ryu 
Citation
 Free Radical Biology and Medicine, Vol.50(9) : 1039~1052, 2011 
Journal Title
 Free Radical Biology and Medicine 
ISSN
 0891-5849 
Issue Date
2011
Abstract
Reactive oxygen species (ROS) contribute to chronic airway inflammation, and NADPH oxidase (Nox) is an important source of ROS. However, little is known of the role that ROS play in chronic upper respiratory tract inflammation. We investigated the mechanism of ROS generation and its association with mucin gene overexpression in the nasal epithelium. The level of platelet-derived growth factor (PDGF) expression was increased in sinusitis mucosa, and high-level PDGF expression induced intracellular ROS, followed by MUC8 gene overexpression in normal human nasal epithelial cells. Knockdown of Nox4 expression with Nox4 siRNA decreased PDGF-induced intracellular ROS and MUC8 expression. Infection with an adenovirus containing Nox4 cDNA resulted in Nox4 overexpression and increased intracellular levels of ROS and MUC8 expression. PDGF and Nox4 overexpression are essential components of intracellular ROS generation and may contribute to chronic inflammation in the nasal epithelium through induction of MUC8 overexpression.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93299
DOI
10.1016/j.freeradbiomed.2011.01.014
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
1. 연구논문 > 5. Research Institutes > 생체방어연구센터
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0891584911000347
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