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Importance of region-specific epithelial rearrangements in mouse rugae development

Authors
 Wern-Joo Sohn  ;  Hitoshi Yamamoto  ;  Hong-In Shin  ;  Zae Young Ryoo  ;  Sanggyu Lee  ;  Yong-Chul Bae  ;  Han-Sung Jung  ;  Jae-Young Kim 
Citation
 CELL AND TISSUE RESEARCH, Vol.344(2) : 271-277, 2011 
Journal Title
CELL AND TISSUE RESEARCH
ISSN
 0302-766X 
Issue Date
2011
MeSH
Animals ; Epithelium/embryology ; Epithelium/metabolism ; Female ; Hedgehog Proteins/biosynthesis ; Hedgehog Proteins/genetics ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred ICR ; Palate/embryology* ; Palate/metabolism ; Pregnancy
Keywords
Pattern formation ; Epithelial rearrangement ; Shh ; Rugae formation ; Palatogenesis ; Mouse (ICR)
Abstract
Epithelial appendages on palatal rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of rugae. In order to reveal possible relationships, we investigated the morphological changes of rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and rugae formation.
Full Text
http://link.springer.com/article/10.1007%2Fs00441-011-1148-z
DOI
10.1007/s00441-011-1148-z
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93206
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