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Risk factors of all-cause in-hospital mortality among Korean elderly bacteremic urinary tract infection (UTI) patients.

Authors
 Bum Sik Chin  ;  Myung Soo Kim  ;  Sang Hoon Han  ;  So Youn Shin  ;  Hee Kyung Choi  ;  Yun Tae Chae  ;  Sung Joon Jin  ;  Ji-Hyeon Baek  ;  Jun Yong Choi  ;  Young Goo Song  ;  Chang Oh Kim  ;  June Myung Kim 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.52(1) : 50-55, 2011 
Journal Title
ARCHIVES OF GERONTOLOGY AND GERIATRICS
ISSN
 0167-4943 
Issue Date
2011
MeSH
Age Factors ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Catheter-Related Infections/drug therapy ; Catheter-Related Infections/mortality ; Community-Acquired Infections/mortality ; Cross Infection/drug therapy ; Cross Infection/mortality ; Female ; Hospital Mortality* ; Humans ; Logistic Models ; Male ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Sex Factors ; Urinary Catheterization/adverse effects ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; Urinary Tract Infections/mortality*
Keywords
Bacteremic urinary tract infection in elderly ; Mortality ; Risk factors
Abstract
Urinary tract infection (UTI) is the most frequent cause of bacteremia/sepsis in elderly people and increasing antimicrobial resistance in uropathogens has been observed. To describe the characteristics of bacteremic UTI in elderly patients and to identify the independent risk factors of all-cause in-hospital mortality, a retrospective cohort study of bacteremic UTI patients of age over 65 was performed at a single 2000-bed tertiary hospital. Bacteremic UTI was defined as the isolation of the same organism from both urine and blood within 48 h. Eighty-six elderly bacteremic UTI patients were enrolled. Community-acquired infection was the case for most patients (79.1%), and Escherichia coli accounted for 88.6% (70/79) among Gram-negative organisms. Non-E. coli Gram-negative organisms were more frequent in hospital-acquired cases and male patients while chronic urinary catheter insertion was related with Gram-positive urosepsis. The antibiotic susceptibility among Gram-negative organisms was not different depending on the source of bacteremic UTI, while non-E. coli Gram-negative organisms were less frequently susceptible for cefotaxime, cefoperazone/sulbactam, and aztreonam. All-cause in-hospital mortality was 11.6%, and functional dependency (adjusted hazard ratio=HR=10.9, 95% confidence interval=95%CI=2.2-54.6) and low serum albumin (adjusted HR=27.0, 95%CI=2.0-361.2) were independently related with increased all-cause in-hospital mortality.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167494310001366
DOI
10.1016/j.archger.2010.05.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수)
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Shin, So Youn(신소연)
Chin, Bum Sik(진범식)
Jin, Sung Joon(진성준)
Chae, Yun Tae(채윤태)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93136
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