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Polymorphisms in the intermediate region of VacA impact Helicobacter pylori-induced disease development

Authors
 Kathleen R. Jones  ;  Sungil Jang  ;  Jennifer Y. Chang  ;  Jinmoon Kim  ;  In-Sik Chung  ;  Cara H. Olsen  ;  D. Scott Merrell  ;  Jeong-Heon Cha 
Citation
 JOURNAL OF CLINICAL MICROBIOLOGY, Vol.49(1) : 101-110, 2011 
Journal Title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN
 0095-1137 
Issue Date
2011
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacterial Proteins/genetics* ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Female ; Genetic Variation* ; Helicobacter Infections/microbiology* ; Helicobacter pylori/genetics ; Helicobacter pylori/isolation & purification ; Helicobacter pylori/pathogenicity* ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Sequence Analysis, DNA ; Virulence Factors/genetics* ; Young Adult
Abstract
Helicobacter pylori is the etiological agent of diseases such as gastritis, gastric and duodenal ulcers, and two types of gastric cancers. While some insight has been gained into the etiology of these diverse manifestations, by and large, the reason that some individuals develop more severe disease remains elusive. Recent studies have focused on the roles of H. pylori toxins CagA and VacA on the disease process and have suggested that both toxins are intimately involved. Moreover, CagA and VacA are polymorphic within different H. pylori strains, and particular polymorphisms seem to show a correlation with the development of particular disease states. Among VacA polymorphisms, the intermediate region has recently been proposed to play a major role in disease outcome. In this article, we describe a detailed sequence analysis of the polymorphic intermediate region of vacA from strains obtained from a large South Korean population. We show that polymorphisms found at amino acid position 196 are associated with more severe disease manifestations. Additionally, polymorphisms found at amino acid position 231 are linked to disease in strains that carry the non-EPIYA-ABD allele of CagA. Collectively, these data help explain the impact of the VacA intermediate region on disease and lead to the hypothesis that there are allele-driven interactions between VacA and CagA.
Files in This Item:
T201101210.pdf Download
DOI
10.1128/JCM.01782-10
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Moon(김진문)
Jang, Sungil(장성일) ORCID logo https://orcid.org/0000-0001-6144-6899
Cha, Jeong Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93133
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