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Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma.

Title
 Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. 
Authors
 Jeong-Dan Cha ; ShengJin Li ; In-Ho Cha 
Issue Date
2011
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Citation
 Head & Neck , Vol.33(5) : 627~637, 2011 
Abstract
BACKGROUND: Increased cytoplasmic HuR expression has been noted in several cancer types, where it may contribute to the increased cyclooxygenase-2 (COX-2) expression observed during tumorigenesis and metastasis. METHODS: To assess the correlation between COX-2 and HuR in oral squamous cell carcinoma (OSCC), the expression patterns of HuR and COX-2 were assessed via immunohistochemistry analyses of 103 OSCC samples. RESULTS: Cytoplasmic HuR expression was significantly associated with COX-2 expression (p < .025) and lymph node metastasis (p < .050) and distant metastasis (p < .025). In multivariate analysis, cytoplasmic HuR expression was identified as an independent prognostic parameter for reduced overall survival. The inhibition of HuR expression by siRNA or leptomycin B (LMB) caused a reduction in the inducibility of COX-2 in oral cancer cells. CONCLUSION: Our results indicate that the cytoplasmic expression of HuR is associated with COX-2 expression in OSCCs and HuR can regulate COX-2 expression in oral cancer cell lines.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93067
DOI
10.1002/hed.21507
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral and Maxillofacial Surgery
1. 연구논문 > 5. Research Institutes > Oral Cancer Research Institute
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/hed.21507/abstract;jsessionid=69647A1433E946DB0134525A353EB4E3.f02t01
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