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Inadequate cytology in thyroid nodules: should we repeat aspiration or follow-up?

Title
Inadequate cytology in thyroid nodules: should we repeat aspiration or follow-up?
Authors
Jung Hyun Yoon;Hee Jung Moon;Jin Young Kwak;Eun-Kyung Kim
Issue Date
2011
Journal Title
Annals of Surgical Oncology
ISSN
1068-9265
Citation
Annals of Surgical Oncology, Vol.18(5) : 1282~1289, 2011
Abstract
BACKGROUND: To evaluate how to correctly manage thyroid nodules showing inadequate cytology after ultrasound (US)-guided fine-needle aspiration biopsy (US-FNAB). MATERIALS AND METHODS: A total of 393 thyroid nodules with inadequate cytology in 351 patients (M:F = 40:311, mean age: 49.3 years) with surgery or follow-up US-FNAB for at least 1 year were included in this study. Among them, 293 (74.6%) were benign and 100 (25.4%) were malignant on final reference results. Clinical characteristics and US features were reviewed and compared. RESULTS: Malignancy rates (39.5%) of nodules having suspicious US feature were significantly higher than those (10.9%) of nodules without any suspicious US feature (P < .001). Malignancy rates of solid nodules, mainly solid nodules, and mainly cystic nodules were 29.2, 16.7, and 9.5%, respectively, with significant differences (P = .016). Malignancy rates of nodules assessed as suspicious malignant to probably benign in composition are: 39.1-12.8% (P < .001) in solid nodules, 42.1-9.2% (P = .001) in mainly solid nodules, and 50.0-5.3% (P = .04) in mainly cystic nodules. CONCLUSIONS: In nodules with inadequate cytology, follow-up US can be considered over repeat aspiration if there are no suspicious US features present, especially in mainly cystic nodules.
URI
http://link.springer.com/article/10.1245%2Fs10434-011-1605-7

http://ir.ymlib.yonsei.ac.kr/handle/22282913/93040
DOI
10.1245/s10434-011-1605-7
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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