Cited 29 times in
Preoperative serum CA 19-9 level as a predictive factor for recurrence after curative resection in biliary tract cancer.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박승우 | - |
dc.contributor.author | 박정엽 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 이경주 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 정문재 | - |
dc.contributor.author | 정재복 | - |
dc.contributor.author | 김경식 | - |
dc.date.accessioned | 2014-12-20T16:36:34Z | - |
dc.date.available | 2014-12-20T16:36:34Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93039 | - |
dc.description.abstract | BACKGROUND: Complete surgical removal of biliary tract cancer (BTC) offers the only chance of cure; however, long-term survival remains very limited because of frequent recurrence after surgery. The purpose of our study was to evaluate whether the preoperative serum carbohydrate antigen (CA) 19-9 level could predict recurrence after curative resection of BTC. METHODS: We performed a retrospective review of the medical records of patients who were diagnosed with BTC and underwent curative resection. The optimal cutoff value for the preoperative serum level of CA 19-9 that predicted recurrence was determined by a ROC curve. Preoperative and postoperative risk factors for recurrence were evaluated using log-rank test. RESULTS: A total of 101 patients were eligible for this study. The optimal cutoff value of preoperative serum CA 19-9 level to predict recurrence was 55 U/mL. Forty-five patients (44.6%) experienced recurrence after curative resection with a median follow-up period of 28.4 months. Recurrence occurred in 33 (61.1%) of 54 patients with CA 19-9 levels ≥55 U/mL compared with only 12 (25.5%) of 47 patients with CA 19-9 levels <55 U/mL. The recurrence rate was significantly higher in patients with baseline CA 19-9 serum levels ≥55 U/mL (hazard ratio, 3.282; 95% confidence interval, 1.684-6.395; P < 0.001). CONCLUSIONS: Elevated preoperative serum CA 19-9 was associated with a high risk of recurrence after curative resection of BTC. Different treatment plans might be needed for patients with BTC and high serum levels of CA 19-9. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1651~1656 | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biliary Tract Neoplasms/blood* | - |
dc.subject.MESH | Biliary Tract Neoplasms/surgery* | - |
dc.subject.MESH | Biomarkers, Tumor/blood* | - |
dc.subject.MESH | CA-19-9 Antigen/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/blood* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/diagnosis* | - |
dc.subject.MESH | Postoperative Complications* | - |
dc.subject.MESH | Preoperative Care | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Preoperative serum CA 19-9 level as a predictive factor for recurrence after curative resection in biliary tract cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Moon Jae Chung | - |
dc.contributor.googleauthor | Kyong Joo Lee | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Seung Woo Park | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Jae Bock Chung | - |
dc.contributor.googleauthor | Jeong Youp Park | - |
dc.identifier.doi | 10.1245/s10434-010-1529-7 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A02656 | - |
dc.contributor.localId | A03602 | - |
dc.contributor.localId | A03706 | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A02993 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 21210227 | - |
dc.identifier.url | http://link.springer.com/article/10.1245%2Fs10434-010-1529-7 | - |
dc.subject.keyword | Curative Resection | - |
dc.subject.keyword | Gallbladder Cancer | - |
dc.subject.keyword | Carbohydrate Antigen | - |
dc.subject.keyword | Preoperative Serum | - |
dc.subject.keyword | Biliary Tract Cancer | - |
dc.contributor.alternativeName | Park, Seung Woo | - |
dc.contributor.alternativeName | Park, Jeong Youp | - |
dc.contributor.alternativeName | Bang, Seung Min | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Lee, Kyong Joo | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.alternativeName | Chung, Moon Jae | - |
dc.contributor.alternativeName | Chung, Jae Bock | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Park, Seung Woo | - |
dc.contributor.affiliatedAuthor | Park, Jeong Youp | - |
dc.contributor.affiliatedAuthor | Bang, Seung Min | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Lee, Kyong Joo | - |
dc.contributor.affiliatedAuthor | Chung, Moon Jae | - |
dc.contributor.affiliatedAuthor | Chung, Jae Bock | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1651 | - |
dc.citation.endPage | 1656 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.18(6) : 1651-1656, 2011 | - |
dc.identifier.rimsid | 27989 | - |
dc.type.rims | ART | - |
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