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In vivo hepatic differentiation potential of human cord blood-derived mesenchymal stem cells

Title
 In vivo hepatic differentiation potential of human cord blood-derived mesenchymal stem cells 
Authors
 Sinyoung Kim ; Han-Soo Kim ; Hyun Ok Kim ; Eugene Lee 
Issue Date
2011
Journal Title
 International Journal of Molecular Medicine 
ISSN
 1107-3756 
Citation
 International Journal of Molecular Medicine, Vol.27(5) : 701~706, 2011 
Abstract
Although recent studies have demonstrated the in vitro hepatic differentiation potential of mesenchymal stem cells (MSCs), the evidence supporting the in vivo engraftment of MSCs, hepatic differentiation and improvement of hepatic function is still lacking. We investigated in vivo hepatic differentiation potential and therapeutic effect of cord blood derived-MSCs (CBMSCs) transplantation in a cirrhotic rat model. CBMSCs (2 x 10(6)) were infused in Wistar rats with thioacetamide-induced chronic liver injury. Biochemical markers, liver fibrosis and engraftment of CBMSCs were assessed. Infused CBMSCs were detected in the perivascular or fibrous region of the liver and did not acquire mature hepatic phenotypes. There was no difference in biochemical markers and in the area of liver fibrosis between the experimental and placebo groups. After infusion of CBMSCs in our experimental cirrhotic rat model we did not observe an improvement of liver function and liver fibrosis. Inversely, CBMSCs could have a pro-fibrogenic potential suggesting that a cautious approach is required in future research
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92940
DOI
10.3892/ijmm.2011.627
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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Link
 http://www.spandidos-publications.com/ijmm/27/5/701?text=abstract
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