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Bcl-XL prevents serum deprivation-induced oxidative stress mediated by Romo1

Authors
 김형중 ; 신정아 
Citation
 Oncology Reports, Vol.25(5) : 1337~1342, 2011 
Journal Title
 Oncology Reports 
ISSN
 1021-335X 
Issue Date
2011
Abstract
B-cell lymphoma-extra large (Bcl-XL) has been known to suppress serum deprivation-induced cell death, while reactive oxygen species modulator 1 (Romo1) is responsible for a serum deprivation-induced increase in reactive oxygen species (ROS). Therefore, we investigated whether Bcl-XL expression could inhibit the serum deprivation-induced increase in ROS and cell death, which are mediated by Romo1. We found that Bcl-XL expression effectively blocked serum deprivation- and Romo1-triggered ROS generation. Bcl-XL also inhibited apoptotic cell death induced by both serum deprivation and oxidative stress. From these results, we suggest that increased Bcl-XL expression, which is observed in many cancer cells, confers resistance to oxidative stress in the cancer cells by suppressing Romo1-mediated oxidative stress
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92910
DOI
10.3892/or.2011.1210
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.spandidos-publications.com/or/25/5/1337
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