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Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin

Authors
 Minyoung Jung ; Sanghoon Lee ; Eung Ho Choi ; Seung Hun Lee ; Byeong Deog Park ; Mi Jung Kwon ; Jonghwan Bae ; Sekyoo Jeong ; Jong-Kyung Youm ; Hwa-young Park 
Citation
 Experimental Dermatology, Vol.20(4) : 314~319, 2011 
Journal Title
 Experimental Dermatology 
ISSN
 0906-6705 
Issue Date
2011
Abstract
Recently, we reported on the anti-ageing effects of K6PC-5. This compound induced keratinocyte differentiation and fibroblast proliferation by increasing sphingosine-1 phosphate synthesis. We performed this study to confirm the anti-ageing effects of new synthetic products (the K6EAA series) derived from K6PC-5 through an amino group induction. Cellular responses such as differentiation, proliferation and calcium mobilization were investigated using cultured human keratinocytes and fibroblasts. Also, we measured the expressions of collagen mRNA and protein using real time RT-PCR and ELISA, respectively. The K6EAA-L12 product, selected by in vitro screening, was evaluated for anti-ageing effects on intrinsically and extrinsically (photo) aged models of hairless mice. In the intrinsically aged murine skin, K6EAA-L12 showed anti-ageing effects by activating collagen synthesis, eventually causing dermal thickening. Also, in the photo-aged skin, the dermal collagen density and dermal thickness were increased. In photo-aged murine skin, K6EAA-L12 increased stratum corneum integrity by increasing corneodesmosome density and improved the barrier recovery rate. However, there were no changes in the expressions of epidermal differentiation maker proteins. In conclusion, topical K6EAA-L12, a new synthetic K6PC-5 derivative, improves intrinsically and extrinsically (photo) aged skin by increasing the collagen density and improving the skin barrier function.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92876
DOI
10.1111/j.1600-0625.2010.01185.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2010.01185.x/abstract
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