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Treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser: a prospective analysis of 35 patients.

Title
 Treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser: a prospective analysis of 35 patients.
Authors
 SUNG BIN CHO; HEE JUNG KIM; JU HEE LEE; YOUNG KOO KIM; SANG JU LEE; SEONGMIN NOH
Issue Date
2011
Journal Title
 Dermatologic Surgery
ISSN
 1076-0512
Citation
 Dermatologic Surgery, Vol.37(4) : 433~438, 2011
Abstract
BACKGROUND: Treatment of syringoma aims to destroy the dermal tumor using methods that can include surgical excision, electrodessication, cryosurgery, chemical peeling, and laser ablation, but complete removal of syringomas is often unsuccessful, and recurrence occurs frequently. OBJECTIVE: To investigate the therapeutic efficacy of an ablative 10,600-nm carbon dioxide fractional laser system (CO(2) FS) for the treatment of periorbital syringomas. METHODS: Thirty-five patients with periorbital syringomas were treated with two sessions of CO(2) FS at 1-month intervals. Laser fluences were delivered in two or three passes over the lower eyelids, using a pulse energy of 100 mJ and a density of 100 spots/cm(2) . Clinical improvement was assessed by comparing pre- and post-treatment clinical photographs and patient satisfaction rates. We examined the histological features of human periorbital syringomas treated with CO(2) FS. RESULTS: Evaluation of clinical results 2 months after treatment showed that 15 of the 35 patients (42.9%) demonstrated marked (51-75%) clinical improvement, 12 (34.3%) had moderate (26-50%) clinical improvement, five (14.3%) showed minimal (0-25%) improvement, and three (8.6%) showed near total (≥75%) improvement. Clinical improvement scores were less 4 months after the second CO(2) FS treatment (not statistically significant). The mean maximal depth of the necrotic column was 1,236.3 μm. A specimen obtained from the infraorbital area immediately after treatment showed formation of necrotic columns on the interfollicular skin. CONCLUSION: The use of CO(2) FS can have a positive therapeutic effect on periorbital syringomas
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92869
DOI
10.1111/j.1524-4725.2011.01915.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1524-4725.2011.01915.x/abstract
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