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Grape seed extract regulates androgen receptor-mediated transcription in prostate cancer cells through potent anti-histone acetyltransferase activity.

Title
 Grape seed extract regulates androgen receptor-mediated transcription in prostate cancer cells through potent anti-histone acetyltransferase activity. 
Authors
 Si Yong Park ; Yoo-Hyun Lee ; Ho-Geun Yoon ; Han-Joon Hwang ; Ok-Hee Lee ; Hyo-Kyoung Choi ; Ah-Reum Seong ; Kyung-Chul Choi 
Issue Date
2011
Journal Title
 Journal of Medicinal Food 
ISSN
 1096-620X 
Citation
 Journal of Medicinal Food, Vol.14(1-2) : 9~16, 2011 
Abstract
Histone acetylation, which is regulated by histone acetyltransferases (HATs) and deacetylases, is an epigenetic mechanism that influences eukaryotic transcription. Significant changes in histone acetylation are associated with cancer; therefore, manipulating the acetylation status of key gene targets is likely crucial for effective cancer therapy. Grape seed extract (GSE) has a known protective effect against prostate cancer. Here, we showed that GSE significantly inhibited HAT activity by 30-80% in vitro (P < .05). Furthermore, we demonstrated significant repression of androgen receptor (AR)-mediated transcription by GSE in prostate cancer cells by measuring luciferase activity using a pGL3-PSA construct bearing the AR element in the human prostate cancer cell line LNCaP (P < .05). GSE treatment also decreased the mRNA level of the AR-regulated genes PSA and NKX 3.1. Finally, GSE inhibited growth of LNCaP cells. These results indicate that GSE potently inhibits HAT, leading to decreased AR-mediated transcription and cancer cell growth, and implicate GSE as a novel candidate for therapeutic activity against prostate cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92851
DOI
10.1089/jmf.2010.1264
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
1. 연구논문 > 1. College of Medicine > Dept. of Life Science
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
Yonsei Authors
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Link
 http://online.liebertpub.com/doi/abs/10.1089/jmf.2010.1264
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