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Interval growth of probably benign breast lesions on follow-up ultrasound: how can these be managed?

 Hee Jung Moon ; Eun-Kyung Kim ; Min Jung Kim ; Jung Hyun Yoon ; Jin Young Kwak 
 European Radiology, Vol.21(5) : 908~918, 2011 
Journal Title
 European Radiology 
Issue Date
OBJECTIVES: To investigate the malignancy rate in probably benign lesions with interval growth on follow-up ultrasound (US) and the cut-off values for predicting malignancy. METHODS: By retrospective reviewing 19,435 US examinations assessed as probably benign lesions, a total of 214 lesions with interval growth in 199 patients were included. The increased volume (%V),%V per month, the most increased diameter (D), and D per month were compared between malignant and benign lesions. Malignancy rates were compared between lesions with or without newly developed suspicious malignant features. RESULTS: Twenty-two (10.3%) malignancies showed significant increase in%V,%V per month, D, and D per month compared with 192 (89.7%) benign lesions (p = 0.0083, <0.0001, <0.0001, and <0.0001, respectively). Fifteen (38.5%) of 39 lesions where suspicious features developed proved malignant, whereas 7 (4%) out of 175 without were malignant (p = 0.0011). In nodules without suspicious features, 24.2% of%V per month and 1.9 mm of D per month showed high sensitivity (85.7% and 71.4%) and specificity (67.8% and 97.6%) for predicting malignancy. CONCLUSIONS: Probably benign lesions with interval growth should undergo prompt biopsy because of the 10.3% malignancy rate. In lesions where suspicious features developed, the malignancy rate increased to 38.5%.
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1. 연구논문 > 1. College of Medicine > Dept. of Radiology
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