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Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor

Title
Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor
Authors
Liwen Li;Hyuk-Jae Kwon;Han-Sung Jung;Sung-Won Cho;Hayato Ohshima;Hidemitsu Harada
Issue Date
2011
Journal Title
Gene Expression Patterns
ISSN
1567-133X
Citation
Gene Expression Patterns, Vol.11(3-4) : 163~170, 2011
Abstract
Recent studies have demonstrated the existence of dental stem cells in the continuously growing tooth. However, much remains to be learned about the complex mechanism involving stem cells during tooth development. We determined the expression patterns of four stem cell markers ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisors between embryonic day (E) 11 and postnatal day (PN) 20. ABCG2 was localized strongly in the perivascular region of the incisor mesenchyme from E11 to PN20, and in the odontoblasts from E18 to PN20. Bmi-1 was expressed in both the dental epithelium and mesenchyme from E11 to E14. The expression of Bmi-1 was noticeably reduced at E16, and was restricted to the apical bud from E16 to PN20. Oct-3/4 was localized in the nucleus of the cells in the superficial layer and stellate reticulum within the dental epithelium from E11 to E14 and in the apical bud from E16 to PN20. Meanwhile, once the ameloblasts and odontoblasts began to appear at E16, they expressed Oct-3/4 in the cytoplasm. Yap was expressed in most of the basal cells of the incisor dental epithelium from E11 to E14, but was expressed mainly in the transit-amplifying (TA) cells within the basal cell layer from E16 to PN20. The unique and overlapping expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap suggest the independent and interactive functions of the four stem cell markers in the developing mouse incisor.
URI
http://www.sciencedirect.com/science/article/pii/S1567133X1000116X

http://ir.ymlib.yonsei.ac.kr/handle/22282913/92806
DOI
10.1016/j.gep.2010.11.001
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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