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Neuroprotective effects of Eriobotrya japonica against β-amyloid-induced oxidative stress and memory impairment

Title
Neuroprotective effects of Eriobotrya japonica against β-amyloid-induced oxidative stress and memory impairment
Authors
Mi-Jeong Kim;Jeongmin Lee;Ho-Geun Yoon;Woo Jin Jun;Young Jun Kim;Hum-Young Baek;Yung-Jae Kim;Yoo-Hyun Lee;Ah-Reum Seong
Issue Date
2011
Journal Title
Food and Chemical Toxicology
ISSN
0278-6915
Citation
Food and Chemical Toxicology, Vol.49(4) : 780~784, 2011
Abstract
The generation of oxygen free radicals and oxidative damage is believed to be involved in the pathogenesis of neurodegenerative disorders. Eriobotrya japonica has been used to treat several diseases in East Asia. In this study, we investigated the protective effect of an E. japonica extract against Aβ peptide-induced oxidative stress. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay demonstrated that the E. japonica extract scavenged approximately 40% of DPPH radicals. Also, treatment of the E. japonica extract inhibited Aβ(1-42)-mediated neuronal cell death. Furthermore, treatment of E. japonica extract efficiently suppressed the increase in intracellular ROS triggered by the Aβ(1-42) peptide. Importantly, mice pre-treated with the E. japonica extract showed restoration of alternation behavior and reversal of Aβ(1-42)-induced memory impairment. Consequently, the E. japonica extract substantially inhibited the increase in lipid peroxidation and restored superoxide dismutase activity. These results suggest that E. japonica protects from oxidative stress and cognitive deficits induced by the Aβ peptide.
URI
http://www.sciencedirect.com/science/article/pii/S0278691510007015

http://ir.ymlib.yonsei.ac.kr/handle/22282913/92748
DOI
10.1016/j.fct.2010.11.043
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
Yonsei Authors
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