Journal of Korean Academy of Oral Health (대한구강보건학회지), Vol.35(1) : 10~17, 2011
Journal of Korean Academy of Oral Health (대한구강보건학회지)
Objectives. The aim of this study was to evaluate the antimicrobial and anti-plaque effect of dentifrice containing 24% baking
soda and 0.3% triclosan in vitro and in clinical trial.
Methods. This study was composed of two parts. The first part evaluated in vitro antibacterial effect of dentifrices containing
baking soda or baking soda with triclosan by minimum inhibition concentration (MIC) of alamar blue staining. The second part
was to evaluate anti-plaque effects by a randomized, double-blind clinical study. A total of 73 subjects were enrolled in this study,
and they were all healthy adult volunteers who provided informed consent. They were divided into three groups, which were the
baking soda group (dentifrice containing 24% baking soda), the baking soda/triclosan group (dentifrice containing 24% baking soda
and 0.3% triclosan) and the control group. All groups were instructed to perform tooth brushing more than two times per day
and not use the other oral hygiene products. The plaque was measured by Turesky modification of Quigley-Hein index in the
six representative teeth. All subjects were evaluated at baseline, four weeks and eight weeks.
Results. According to the antimicrobial effect observed in the in vitro study, the baking soda with triclosan dentifrices group showed
the lowest level of MIC to S. mutans (0.04%) and P. gingivalis (0.04%) compared to the control and other test groups. According
to the effect of reducing plaque formation in clinical study, the baking soda/triclosan and the baking soda dentifrice groups showed
significant reduction of plaque formation at four weeks (p＜0.05), and additional reduction of plaque formation eight week laters
Conclusions. The dentifrice containing 24% of baking soda and 0.3% of triclosan showed more antibacterial and anti-plaque effects
than the control or baking soda group by in vitro study and clinical trial.