Cited 41 times in

Binary mixing of micelles using Pluronics for a nano-sized drug delivery system

Authors
 Eun Seong Lee ; Young Taik Oh ; Kyung Taek Oh ; Ho-Taek Song ; Ji Hoon Kim ; Jungmin Yun ; Byungtae Park ; Myounghwa Nam ; Yu Seok Youn 
Citation
 Colloids and Surfaces B-Biointerfaces, Vol.82(1) : 190~195, 2011 
Journal Title
 Colloids and Surfaces B-Biointerfaces 
ISSN
 0927-7765 
Issue Date
2011
Abstract
Pluronics with different structural compositions and properties are used for several applications, including drug delivery systems. We developed a binary mixing system with two Pluronics, L121/P123, as a nano-sized drug delivery carrier. The lamellar-forming Pluronic L121 (0.1 wt%) was incorporated with Pluronic P123 to produce nano-sized dispersions (in case of 0.1 and 0.5 wt% P123) with high stability due to Pluronic P123 and high solubilization capacity due to Pluronic L121. The binary systems were spherical and less than 200-nm diameter, with high thermodynamic stability (at least 2 weeks) in aqueous solution. The CMC of the binary system was located in the middle of the CMC of each polymer. In particular, the solubilization capacity of the binary system (0.1/0.1 wt%) was higher than mono-systems of P123. The main advantage of binary systems is overcoming limitations of mono systems to allow tailored mixing of block copolymers with different physicochemical characteristics. These nano-sized systems may have potential as anticancer drug delivery systems with simple preparation method, high stability, and high loading capacity.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92704
DOI
10.1016/j.colsurfb.2010.08.033
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.sciencedirect.com/science/article/pii/S0927776510004911
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse