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Relation of inflammation and left atrial remodeling in atrial fibrillation occurring in early phase of acute myocardial infarction.

Authors
 Hye Jin Hwang ; Jong-Won Ha ; Sung Soon Kim ; Namsik Chung ; Yangsoo Jang ; Moon-Hyoung Lee ; Min-Soo Ahn ; Jaedeok Kim ; Eun-Hee Choi ; Boyoung Joung 
Citation
 International Journal of Cardiology, Vol.146(1) : 28~31, 2011 
Journal Title
 International Journal of Cardiology 
ISSN
 0167-5273 
Issue Date
2011
Abstract
BACKGROUND: Inflammation is frequently associated with the development of atrial fibrillation (AF). This study was performed to investigate whether the high sensitivity C-reactive protein (hsCRP) present during acute inflammation could predict early AF and its relationship to left atrial (LA) enlargement in acute myocardial infarction (AMI). METHODS AND RESULTS: In 401 consecutive AMI patients, AF predictors were compared between those with and without early AF. Early AF was defined as AF developing within 24 h after AMI. In order to identify the difference in the AF predictors according to LA enlargement, patients were subgrouped according to an LA volume index (LAVI) of <32 cm(3)/m(2) (group 1, n=321) and ≥32 cm(3)/m(2) (group 2, n=80). Thirty-three (8.2%) patients developed early AF including 17 (5.3%) and 16 (20%) patients in groups 1 and 2, respectively. The independent predictors of AF were multivessel involvement (OR=2.51, p=0.03), LAVI≥32 cm(3)/m(2) (OR=2.47, p=0.03), higher hsCRP (OR=2.24, p=0.05), and old age (OR=1.06, p=0.01) in all patients. In the subgroups divided by the LAVI, higher hsCRP was a predictor of early AF only in group 1 (OR=4.56, p=0.004). CONCLUSIONS: Our results suggest that multivessel involvement, enlarged LA, higher hsCRP, and old age are predictors of early AF after AMI. However, hsCRP could be strongly related to early AF only in AMI patients with less dilated LA.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92654
DOI
10.1016/j.ijcard.2009.05.065
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biostatistics
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0167527309006470
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