Cited 17 times in

Thoracoscopic lobectomy is associated with superior compliance with adjuvant chemotherapy in lung cancer.

Title
Thoracoscopic lobectomy is associated with superior compliance with adjuvant chemotherapy in lung cancer.
Authors
Jin Gu Lee;Byoung Chul Cho;Kyung Young Chung;Dae Joon Kim;In Kyu Park;Chang Young Lee;Mi Kyung Bae
Issue Date
2011
Journal Title
Annals of Thoracic Surgery
ISSN
0003-4975
Citation
Annals of Thoracic Surgery, Vol.91(2) : 344~348, 2011
Abstract
BACKGROUND: Although the survival benefit of adjuvant chemotherapy for nonsmall-cell lung cancer has been proved, 50% to 86% of patients received all planned cycles of chemotherapy. A thoracoscopic procedure may enable more effective administration of adjuvant chemotherapy than a thoracotomy. However, a well-balanced comparison is lacking. METHODS: Patients who underwent pulmonary resection and received platinum-based double adjuvant chemotherapy for nonsmall-cell lung cancer were identified from a prospective database. A propensity score-matched analysis was performed to obtain a well-balanced comparison between thoracoscopy and thoracotomy to determine compliance of adjuvant chemotherapy. RESULTS: Seventy-four patients (group A) with thoracoscopy and 278 patients with thoracotomy received adjuvant chemotherapy. Through 1:1 matching, 74 patients (group B) were selected from the thoracotomy group. A higher percentage of group A received four cycles of the planned adjuvant chemotherapy (95.9% versus 82.4%, p = 0.015). There was a trend toward better compliance in group A with four cycles of adjuvant chemotherapy without reduced dose (83.8% versus 73.0%, p = 0.162), and four cycles of adjuvant chemotherapy without delayed or reduced dose (70.3% versus 62.2%, p = 0.385). CONCLUSIONS: Thoracoscopy showed better compliance with adjuvant chemotherapy after pulmonary resection for nonsmall-cell lung cancer.
URI
http://www.sciencedirect.com/science/article/pii/S0003497510021090

http://ir.ymlib.yonsei.ac.kr/handle/22282913/92649
DOI
10.1016/j.athoracsur.2010.09.031
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Thoracic & Cardiovascular Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse