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Molecular imaging with terahertz waves

Authors
 Seung Jae Oh ; Jihye Choi ; Joo-Hiuk Son ; Seungjoo Haam ; Jin-Suck Suh ; Yong-Min Huh ; Kwangyeol Lee ; Jae Yeon Park ; Inhee Maeng 
Citation
 Optics Express, Vol.19(5) : 4009~4016, 2011 
Journal Title
 Optics Express 
ISSN
 1094-4087 
Issue Date
2011
Abstract
We demonstrate a highly sensitive THz molecular imaging (TMI) technique involving differential modulation of surface plasmons induced on nanoparticles and obtain target specific in vivo images of cancers. This technique can detect quantities of gold nanoparticles as small as 15 µM in vivo. A comparison of TMI images with near infrared absorption images shows the superior sensitivity of TMI. Furthermore, the quantification property of TMI is excellent, being linearly proportional to the concentration of nanoparticles. The target specificity issue is also addressed at the ex vivo and cell levels. The high thermal sensitivity of TMI can help extend photonic-based photothermal molecular imaging researches from the in vitro level to the in vivo level. The TMI technique can be used for monitoring drug delivery processes and for early cancer diagnosis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92582
DOI
10.1364/OE.19.004009
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Institute for Medical Convergence
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://www.opticsinfobase.org/oe/abstract.cfm?uri=oe-19-5-4009
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