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A genetic investigation of Korean mummies from the Joseon Dynasty

Title
 A genetic investigation of Korean mummies from the Joseon Dynasty 
Authors
 Na Young Kim ; Hwan Young Lee ; Kyoung-Jin Shin ; Woo Ick Yang ; Myung Jin Park 
Issue Date
2011
Journal Title
 Molecular Biology Reports 
ISSN
 0301-4851 
Citation
 Molecular Biology Reports, Vol.38(1) : 115~121, 2011 
Abstract
Two Korean mummies (Danwoong-mirra and Yoon-mirra) found in medieval tombs in the central region of the Korean peninsula were genetically investigated by analysis of mitochondrial DNA (mtDNA), Y-chromosomal short tandem repeat (Y-STR) and the ABO gene. Danwoong-mirra is a male child mummy and Yoon-mirra is a pregnant female mummy, dating back about 550 and 450 years, respectively. DNA was extracted from soft tissues or bones. mtDNA, Y-STR and the ABO gene were amplified using a small size amplicon strategy and were analyzed according to the criteria of ancient DNA analysis to ensure that authentic DNA typing results were obtained from these ancient samples. Analysis of mtDNA hypervariable region sequence and coding region single nucleotide polymorphism (SNP) information revealed that Danwoong-mirra and Yoon-mirra belong to the East Asian mtDNA haplogroups D4 and M7c, respectively. The Y-STRs were analyzed in the male child mummy (Danwoong-mirra) using the AmpFlSTR® Yfiler PCR Amplification Kit and an in-house Y-miniplex plus system, and could be characterized in 4 loci with small amplicon size. The analysis of ABO gene SNPs using multiplex single base extension methods revealed that the ABO blood types of Danwoong-mirra and Yoon-mirra are AO01 and AB, respectively. The small size amplicon strategy and the authentication process in the present study will be effectively applicable to future genetic analyses of various forensic and ancient samples.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92575
DOI
10.1007/s11033-010-0084-4
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Forensic Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs11033-010-0084-4
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