Cited 22 times in
Mechanism of alveolar bone loss in a collagen-induced arthritis model in mice
DC Field | Value | Language |
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dc.contributor.author | 박정철 | - |
dc.contributor.author | 이수곤 | - |
dc.contributor.author | 정임희 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 최성호 | - |
dc.contributor.author | 김종관 | - |
dc.contributor.author | 김창성 | - |
dc.contributor.author | 박용범 | - |
dc.date.accessioned | 2014-12-20T16:20:56Z | - |
dc.date.available | 2014-12-20T16:20:56Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92549 | - |
dc.description.abstract | OBJECTIVE: the aim of this study was to understand the cellular/molecular mechanisms of periodontal breakdown in a collagen-induced arthritis (CIA) model in mice to enhance the understanding of rheumatoid arthritis (RA)-associated alveolar bone loss in humans. MATERIALS AND METHODS: all analyses were performed on paired samples from CIA and control group mice. Mandibles were retrieved for micro-computed tomography (micro-CT), histomorphometric analysis, and isolation of alveolar bone cells (ABCs). In vitro osteoclastogenic/osteogenic/adipogenic potentials of ABCs were evaluated and the mRNA expression of downstream effector genes was assessed. Bone formation of ABCs was assessed using an ectopic transplantation model. RESULTS: histomorphometric and micro-CT data showed that alveolar bone loss was significantly increased in the CIA group (p<0.05). Osteoclastogenesis was significantly increased in the CIA group in vivo (p<0.05), with upregulated mRNA expressions of osteoclastogenesis-associated genes. Osteoblasts appeared to undergo increased apoptosis, and the bone-forming activity of ABCs concomitantly decreased with in vitro osteogenic differentiation and in vivo ectopic transplantation (p<0.05). Also, adipogenesis-associated mRNA expression was highly expressed in the CIA group, resulting in significantly enhanced adipocyte differentiation in vitro (p<0.05). CONCLUSIONS: these data demonstrate that increased osteoclastic activity, decreased bone-forming activity and enhanced adipogenesis promote alveolar bone loss in a CIA model in mice, and they suggest that these mechanisms could account for the same outcome in human RA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 122~130 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipogenesis/physiology | - |
dc.subject.MESH | Alveolar Bone Loss/complications* | - |
dc.subject.MESH | Alveolar Bone Loss/pathology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Arthritis, Experimental/chemically induced | - |
dc.subject.MESH | Arthritis, Experimental/complications | - |
dc.subject.MESH | Arthritis, Experimental/pathology | - |
dc.subject.MESH | Arthritis, Rheumatoid/complications* | - |
dc.subject.MESH | Arthritis, Rheumatoid/pathology | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Collagen | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Mandible/diagnostic imaging | - |
dc.subject.MESH | Mandible/pathology | - |
dc.subject.MESH | Matched-Pair Analysis | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Osteoclasts/pathology* | - |
dc.subject.MESH | Osteogenesis/physiology* | - |
dc.subject.MESH | X-Ray Microtomography/veterinary | - |
dc.title | Mechanism of alveolar bone loss in a collagen-induced arthritis model in mice | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Jung-Chul Park | - |
dc.contributor.googleauthor | Chuanxin Su | - |
dc.contributor.googleauthor | Im-Hee Jung | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Kyoo-Sung Cho | - |
dc.contributor.googleauthor | Chong-Kwan Kim | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Soo-Kon Lee | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.identifier.doi | 10.1111/j.1600-051X.2010.01645.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01653 | - |
dc.contributor.localId | A02889 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A00914 | - |
dc.contributor.localId | A03703 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J01337 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.pmid | 21062340 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2010.01645.x/abstract | - |
dc.subject.keyword | bone resportion | - |
dc.subject.keyword | experimentalarthritis | - |
dc.subject.keyword | mice | - |
dc.subject.keyword | periodontitis | - |
dc.subject.keyword | rheumatoidarthritis | - |
dc.contributor.alternativeName | Park, Jung Chul | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.alternativeName | Jung, Im Hee | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.alternativeName | Kim, Chong Kwan | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Park, Jung Chul | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Kim, Chong Kwan | - |
dc.contributor.affiliatedAuthor | Jung, Im Hee | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 38 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 122 | - |
dc.citation.endPage | 130 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.38(2) : 122-130, 2011 | - |
dc.identifier.rimsid | 28629 | - |
dc.type.rims | ART | - |
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