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중독성 약물에 대한 보상 기억에서 PKMzeta의 역할

Title
 중독성 약물에 대한 보상 기억에서 PKMzeta의 역할
Other Titles
 The Role of PKMzeta in Drug Reward Memory
Authors
 송민지; 김정훈
Issue Date
2012
Journal Title
 대한정신약물학회지
ISSN
 1017-5717
Citation
 대한정신약물학회지, Vol.23(3) : 83~87, 2012
Abstract
Drug addiction is a chronic brain disease with a high incidence of relapse. Environmental cues that previously and repeatedly associated with drugs of abuse easily evoke relapse to addicts even after long period of drug-free state. Such a long lasting property of conditioning is considered a form of long-term memory and has a strong correlation with synaptic plasticity like long-term potentiation (LTP). Protein kinase M zeta (PKMzeta) has been known to play an important role in the maintenance of long-term memory as well as LTP in various brain areas. Likewise, in a few brain areas examined out of the rewarding circuit, PKMzeta seems to play a similarly important role in the maintenance of conditioned memory. These results suggest that PKMzeta may become a new target to manipulate to reverse pre-formed drug-related memory and accompanied behaviors.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92338
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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