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독성 알코올 중독 환자에 대한 고찰

Title
 독성 알코올 중독 환자에 대한 고찰 
Other Titles
 Clinical Review of Toxic Alcohol Poisoning Cases in Korea 
Authors
 이누가 ; 정성필 ; 김승환 ; 권인호 ; 조영순 ; 김건배 ; 김현진 ; 이경룡 ; 박인철 
Issue Date
2012
Journal Title
 대한임상독성학회지 
ISSN
 1738-1320 
Citation
 대한임상독성학회지, Vol.10(1) : 15~21, 2012 
Abstract
Purpose: Toxic alcohols are responsible for accidental and suicide motivated poisonings, resulting in death or permanent sequelae for the afflicted patients. Major therapeutic modalities in these cases include treatment with alcohol dehydrogenase inhibitors and extracorporeal elimination. There have been a number of case reports of toxic alcohol intoxication in Korea. The purpose of this study was to review the clinical characteristics of patients suffering toxic alcohol intoxication. Methods: We retrospectively reviewed the medical records of patients who presented with toxic alcohol intoxication at 8 emergency departments (ED) from Jun 2005 to Nov 2011. Patients who ingested methanol, isopropyl alcohol, ethylene glycol, and other alcohols except ethanol, were included in this study. The clinical characteristics of these patients were analyzed to include anion and osmolar gap, and estimated concentration of alcohol in the body. Results: During the study period, 21 patients were identified who had ingested toxic alcohol (methanol; 12 patients, ethylene glycol; 9 patients). At ED arrival, the mean anion gap was and the osmolar gap was elevated in 13 patients. Oral and IV ethanol were administrated to 11 patients in order to inhibit alcohol dehydrogenase. Extracorporeal elimination procedures such as hemodialysis were performed in 9 patients. There were no fatalities, but the one patient suffered permanent blindness. Conclusion: This study found that ethylene glycol and methanol were the substances ingested which produced toxic alcohol intoxication. The patients presented with high anion gap metabolic acidosis and were typically treated with oral ethanol and hemodialysis
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92329
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Emergency Medicine
Yonsei Authors
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