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뇌졸중 일차예방을 위한 최신 과학적 근거(2011): 이상지질혈증과 염증

Title
뇌졸중 일차예방을 위한 최신 과학적 근거(2011): 이상지질혈증과 염증
Other Titles
2011 Update of Scientific Statement for the Primary Prevention of Stroke: Dyslipidemia and Inflammation
Authors
한상원;김한영;홍근식;정진상;윤병우;이병철;배희준;오창완;권순억;허지회;나정호;유경호;강규식;조용진;구자성;박종무
Issue Date
2012
Journal Title
대한신경과학회지
ISSN
1225-7044
Citation
대한신경과학회지, Vol.30(3) : 159~169, 2012
Abstract
BACKGROUND: This scientific statement is intended to provide a systematic review of new evidences in dyslipidemia and inflammation for primary stroke prevention. METHODS: Using a structured literature search, we identified major observational studies, clinical trials, meta-analyses, and updated major guidelines published between July 2007 and November 2010. In addition to the brief summary of earlier evidences employed in the first edition of Korean clinical practice guideline for primary prevention of stroke, we summarized the newly identified evidences. RESULTS: For dyslipidemia, observational studies further support a strong association between ischemic stroke and high total and low-density lipoprotein cholesterol and low high-density lipoprotein cholesterol. Two clinical trials and 6 meta-analyses confirm statin efficacy for primary prevention of stroke in high risk patients. Efficacy of other lipid-lowering agents is not established. For inflammation, inflammatory markers might help to identify patients having high risk for stroke or cardiovascular event and to decide whether statin therapy is indicated, but its usefulness for broad population needs to be confirmed. CONCLUSIONS: Writing committee will continue to keep an eye on upcoming evidences to timely update the guideline for primary stroke prevention in dyslipidemia and inflammation.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/92276
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
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